Assay Detail
Binding
CHEMBL4200764
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Binding affinity to ABL1 (64 to 515 residues) (unknown origin) expressed in Escherichia coli by NMR analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 5.31 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4217428 | — | — | 1 | 5.70 |
| CHEMBL4206566 | — | — | 1 | 5.40 |
| CHEMBL1234477 | — | — | 1 | 5.22 |
| CHEMBL4205194 | — | — | 1 | 5.22 |
| CHEMBL4210089 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4217428 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL4206566 | — | Kd | = | 4000.0 | nM | 5.40 |
| CHEMBL1234477 | — | Kd | = | 6000.0 | nM | 5.22 |
| CHEMBL4205194 | — | Kd | = | 6000.0 | nM | 5.22 |
| CHEMBL4210089 | — | Kd | = | 10000.0 | nM | 5.00 |