Assay Detail
Functional
CHEMBL4200980
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Antiviral activity against Dengue virus 1 Djibouti D1/H/IMTSSA/98/606 infected in African green monkey Vero cells assessed as reduction in viral yield after 7 days by qRT-PCR analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | dengue virus type 1 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of Indole Derivatives as Novel and Potent Dengue Virus Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.63 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4212403 | — | — | 1 | 7.33 |
| CHEMBL4205665 | — | — | 1 | 6.76 |
| CHEMBL4215935 | — | — | 1 | 6.61 |
| CHEMBL4212873 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4212403 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4205665 | — | EC50 | = | 173.0 | nM | 6.76 |
| CHEMBL4215935 | — | EC50 | = | 247.0 | nM | 6.61 |
| CHEMBL4212873 | — | EC50 | = | 1600.0 | nM | 5.80 |