Assay Detail
Binding
CHEMBL4201170
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of alpha-crystallin B R120G mutant (unknown origin)-induced intracellular protein aggregation expressed in human HeLa cells or HLE-B3 cells incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis, Evaluation, and Structure-Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.01 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4204376 | — | — | 1 | 7.75 |
| CHEMBL4209249 | — | — | 1 | 7.58 |
| CHEMBL4203007 | — | — | 1 | 7.24 |
| CHEMBL4218328 | — | — | 1 | 7.19 |
| CHEMBL4205794 | — | — | 1 | 6.97 |
| CHEMBL169046 | — | — | 1 | 6.50 |
| CHEMBL225111 | LANOSTEROL | — | 1 | 5.85 |
| CHEMBL4213644 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4204376 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4209249 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4203007 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4218328 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4205794 | — | EC50 | = | 106.0 | nM | 6.97 |
| CHEMBL169046 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL225111 | LANOSTEROL | EC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL4213644 | — | EC50 | - | — | - |