Compound Detail
CHEMBL225111
LANOSTEROL Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC(C)=CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]1(C)CC[C@H](O)C(C)(C)[C@@H]1CC3
Basic Information
| ChEMBL ID | CHEMBL225111 |
| Name | LANOSTEROL |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CAHGCLMLTWQZNJ-BQNIITSRSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
426.7
MW (Da)
8.48
ALogP
1
HBA
1
HBD
20.2
PSA (Ų)
0.45
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 2 meas. best 7.55
EC50 1 meas. best 5.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Kd | 7.55 | 6.73 | 28.0 | 2 |
| Alpha-crystallin B chain CHEMBL3621022 | EC50 | 5.85 | 5.85 | 1420.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | Kd | = | 28.0 | nM | 7.55 | Substrate activity at Naegleria fowleri CYP51 expressed in Escherichia coli HMS-... | 34842434 |
| Unchecked | Kd | = | 1220.0 | nM | 5.91 | Binding affinity to Acanthamoeba castellanii CYP51 expressed in Escherichia coli... | 38683753 |
| Alpha-crystallin B chain | EC50 | = | 1420.0 | nM | 5.85 | Inhibition of alpha-crystallin B R120G mutant (unknown origin)-induced intracell... | 30153006 |
Literature References
Data from ChEMBL 36 via Core Engine