Assay Detail
Binding
CHEMBL5549252
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Binding affinity to Acanthamoeba castellanii CYP51 expressed in Escherichia coli HMS-174 (DE3) cells assessed as dissociation constant by UV-Visible spectrophotometry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Acanthamoeba castellanii |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of Potent and Selective Inhibitors of <i>Acanthamoeba</i>: Structural Insights into Sterol 14α-Demethylase as a Key Drug Target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.28 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3311228 | OTESECONAZOLE | 4.0 | 1 | 8.41 |
| CHEMBL481434 | OBTUSIFOLIOL | — | 1 | 7.52 |
| CHEMBL225111 | LANOSTEROL | — | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3311228 | OTESECONAZOLE | Kd | = | 3.9 | nM | 8.41 |
| CHEMBL481434 | OBTUSIFOLIOL | Kd | = | 30.0 | nM | 7.52 |
| CHEMBL225111 | LANOSTEROL | Kd | = | 1220.0 | nM | 5.91 |