Assay Detail
Binding
CHEMBL4201406
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Plasmodium falciparum DXR
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic (CHEMBL4295619) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum (isolate 3D7) |
Publication
MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.55 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1922604 | — | — | 1 | 7.62 |
| CHEMBL2164257 | FOSMIDOMYCIN SODIUM | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1922604 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2164257 | FOSMIDOMYCIN SODIUM | IC50 | = | 34.0 | nM | 7.47 |