Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4201519

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity in human K562 cells assessed as reduction in cell viability incubated for 72 hrs by cell-QB reagent based assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type K562
Confidence 1 — Organism
Curated By Intermediate

Target

K562 (CHEMBL385)
Type CELL-LINE
Organism Homo sapiens

Publication

Phosphonamidate Prodrugs of a Butyrophilin Ligand Display Plasma Stability and Potent Vγ9 Vδ2 T Cell Stimulation.
Lentini NA, Foust BJ, Hsiao CC, Wiemer AJ, Wiemer DF.
J Med Chem (2018) 61 : 8658 -8669
PubMed 30199251 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.55 4.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4204584 1 4.64
CHEMBL4215122 1 4.62
CHEMBL4215653 1 4.55
CHEMBL4216254 1 4.40
CHEMBL4208921 1 -
CHEMBL4204044 1 -
CHEMBL4203452 1 -
CHEMBL4210700 1 -
CHEMBL4207267 1 -
CHEMBL14060 PHENOL 4.0 1 -
CHEMBL122617 1-NAPHTHOL 1 -
CHEMBL14126 BETANAPHTHOL -1.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4204584 IC50 = 23000.0 nM 4.64
CHEMBL4215122 IC50 = 24000.0 nM 4.62
CHEMBL4215653 IC50 = 28000.0 nM 4.55
CHEMBL4216254 IC50 = 40000.0 nM 4.40
CHEMBL4208921 IC50 > 100000.0 nM -
CHEMBL4204044 IC50 > 100000.0 nM -
CHEMBL4203452 IC50 > 100000.0 nM -
CHEMBL4210700 IC50 > 100000.0 nM -
CHEMBL4207267 IC50 > 100000.0 nM -
CHEMBL14060 PHENOL IC50 > 100000.0 nM -
CHEMBL122617 1-NAPHTHOL IC50 > 100000.0 nM -
CHEMBL14126 BETANAPHTHOL IC50 > 100000.0 nM -