Assay Detail
Functional
CHEMBL4201620
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human OTR expressed in HEK cells assessed as increase in intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.46 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3763342 | — | — | 1 | 8.52 |
| CHEMBL360648 | — | — | 1 | 7.55 |
| CHEMBL4204210 | — | — | 1 | 7.26 |
| CHEMBL4216174 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3763342 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL360648 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4204210 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4216174 | — | EC50 | = | 300.0 | nM | 6.52 |