Assay Detail
Functional
CHEMBL4201656
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Agonist activity at human V1b receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.99 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395429 | OXYTOCIN | 4.0 | 1 | 7.41 |
| CHEMBL3301668 | CARBETOCIN | 3.0 | 1 | 4.57 |
| CHEMBL4204210 | — | — | 1 | - |
| CHEMBL3763342 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395429 | OXYTOCIN | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3301668 | CARBETOCIN | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL4204210 | — | EC50 | - | — | - | |
| CHEMBL3763342 | — | EC50 | - | — | - |