Assay Detail
Binding
CHEMBL4201920
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human CYP1B1 incubated for 45 mins using 7-ethyl-O-resorufin substrate in presence of NADPH regenerating system by fluorescence based ethoxyresorufin-O-deethylase assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting Cytochrome P450 (CYP) 1B1 Enzyme with Four Series of A-Ring Substituted Estrane Derivatives: Design, Synthesis, Inhibitory Activity, and Selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.51 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 6.62 |
| CHEMBL4172273 | — | — | 1 | 6.62 |
| CHEMBL4215891 | — | — | 1 | 6.62 |
| CHEMBL4218514 | — | — | 1 | 6.43 |
| CHEMBL4205335 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4172273 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4215891 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4218514 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4205335 | — | IC50 | = | 540.0 | nM | 6.27 |