Assay Detail
Functional
CHEMBL4201981
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Antiproliferative activity against human HCT116 cells expressing wild type p53 incubated for 72 hrs by MTS assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Inhibition of p53-Murine Double Minute 2 (MDM2) Interactions with 3,3'-Spirocyclopentene Oxindole Derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.33 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191334 | NUTLIN-3 | — | 1 | 5.89 |
| CHEMBL4207959 | — | — | 1 | 5.54 |
| CHEMBL4217905 | — | — | 1 | 5.32 |
| CHEMBL4218748 | — | — | 1 | 4.98 |
| CHEMBL4203529 | — | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4207959 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL4217905 | — | IC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL4218748 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4203529 | — | IC50 | = | 11600.0 | nM | 4.94 |