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Assay Detail

CHEMBL4202382

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs by Griess assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type BV-2
Confidence 1 — Organism
Curated By Intermediate

Target

BV-2 (CHEMBL614781)
Type CELL-LINE
Organism Mus musculus

Publication

Coumarinolignoids and Taraxerane Triterpenoids from Sapium discolor and Their Inhibitory Potential on Microglial Nitric Oxide Production.
Zhang GJ, Pan QM, Zhang YL, Liao HB, Yang YQ, Hou Y, Liang D.
J Nat Prod (2018) 81 : 2251 -2258
PubMed 30350995 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.11 5.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4215196 1 5.77
CHEMBL4203524 1 5.57
CHEMBL4212737 1 5.38
CHEMBL1434 MINOCYCLINE 4.0 1 5.31
CHEMBL4210564 1 5.24
CHEMBL4211474 1 5.14
CHEMBL4214645 1 4.93
CHEMBL4207761 1 4.86
CHEMBL4207883 1 4.85
CHEMBL4202993 1 4.82
CHEMBL4212231 1 4.33
CHEMBL4207343 1 -
CHEMBL258249 ALEURITOLIC ACID 1 -
CHEMBL439422 ACETYL ALEURITOLIC ACID 1 -
CHEMBL4205316 1 -
CHEMBL4215586 1 -
CHEMBL4209162 1 -
CHEMBL4214336 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4215196 IC50 = 1700.0 nM 5.77
CHEMBL4203524 IC50 = 2700.0 nM 5.57
CHEMBL4212737 IC50 = 4200.0 nM 5.38
CHEMBL1434 MINOCYCLINE IC50 = 4900.0 nM 5.31
CHEMBL4210564 IC50 = 5800.0 nM 5.24
CHEMBL4211474 IC50 = 7200.0 nM 5.14
CHEMBL4214645 IC50 = 11800.0 nM 4.93
CHEMBL4207761 IC50 = 13800.0 nM 4.86
CHEMBL4207883 IC50 = 14000.0 nM 4.85
CHEMBL4202993 IC50 = 15300.0 nM 4.82
CHEMBL4212231 IC50 = 46500.0 nM 4.33
CHEMBL4207343 IC50 > 50000.0 nM -
CHEMBL258249 ALEURITOLIC ACID IC50 > 50000.0 nM -
CHEMBL439422 ACETYL ALEURITOLIC ACID IC50 > 50000.0 nM -
CHEMBL4205316 IC50 > 50000.0 nM -
CHEMBL4215586 IC50 > 50000.0 nM -
CHEMBL4209162 IC50 > 50000.0 nM -
CHEMBL4214336 IC50 > 50000.0 nM -