Assay Detail
Binding
CHEMBL4220002
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Inhibition of Bcl-xL (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Beyond the Rule of 5: Lessons Learned from AbbVie's Drugs and Compound Collection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.48 | 10.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 10.26 |
| CHEMBL4228713 | A-1211212 | — | 1 | 7.85 |
| CHEMBL3137309 | VENETOCLAX | 4.0 | 1 | 7.32 |
| CHEMBL376408 | ABT 737 | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443684 | NAVITOCLAX | Ki | = | 0.055 | nM | 10.26 |
| CHEMBL4228713 | A-1211212 | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL3137309 | VENETOCLAX | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL376408 | ABT 737 | Ki | < | 1.0 | nM | - |