Assay Detail
Functional
CHEMBL4220035
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Antiproliferative activity against human Kasumi-1 cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Kasumi 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Fragment-based design, synthesis, biological evaluation, and SAR of 1H-benzo[d]imidazol-2-yl)-1H-indazol derivatives as potent PDK1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.17 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3659990 | — | — | 1 | 7.27 |
| CHEMBL3659991 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3659990 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3659991 | — | IC50 | = | 87.8 | nM | 7.06 |