Assay Detail
Functional
CHEMBL4220745
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antioxidant activity in brain homogenate (unknown origin) assessed as decrease in TBARS formation by UV-visible spectrophotometric method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Not specified |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with neuroprotective role for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.17 | 4.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196 | ASCORBIC ACID | 4.0 | 1 | 4.41 |
| CHEMBL4228084 | — | — | 1 | 4.23 |
| CHEMBL4227873 | — | — | 1 | 4.21 |
| CHEMBL390388 | — | — | 1 | 4.21 |
| CHEMBL601724 | — | — | 1 | 4.21 |
| CHEMBL224702 | — | — | 1 | 4.06 |
| CHEMBL224554 | — | — | 1 | 4.03 |
| CHEMBL1354164 | — | — | 1 | 4.03 |
| CHEMBL34173 | — | — | 1 | - |
| CHEMBL389656 | — | — | 1 | - |
| CHEMBL587104 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196 | ASCORBIC ACID | IC50 | = | 38770.0 | nM | 4.41 |
| CHEMBL4228084 | — | IC50 | = | 59420.0 | nM | 4.23 |
| CHEMBL4227873 | — | IC50 | = | 61820.0 | nM | 4.21 |
| CHEMBL390388 | — | IC50 | = | 62370.0 | nM | 4.21 |
| CHEMBL601724 | — | IC50 | = | 61290.0 | nM | 4.21 |
| CHEMBL224702 | — | IC50 | = | 86460.0 | nM | 4.06 |
| CHEMBL224554 | — | IC50 | = | 93240.0 | nM | 4.03 |
| CHEMBL1354164 | — | IC50 | = | 94010.0 | nM | 4.03 |
| CHEMBL34173 | — | IC50 | = | 106050.0 | nM | - |
| CHEMBL389656 | — | IC50 | = | 100840.0 | nM | - |
| CHEMBL587104 | — | IC50 | = | 264310.0 | nM | - |