Assay Detail
Binding
CHEMBL4222142
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE2 (unknown origin)
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-dependent 3',5'-cyclic phosphodiesterase (CHEMBL2652) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Indole acids as a novel PDE2 inhibitor chemotype that demonstrate pro-cognitive activity in multiple species.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.46 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4228478 | — | — | 1 | 8.30 |
| CHEMBL4229054 | — | — | 1 | 8.15 |
| CHEMBL4224708 | — | — | 1 | 7.75 |
| CHEMBL4228792 | — | — | 1 | 7.51 |
| CHEMBL4226404 | — | — | 1 | 7.42 |
| CHEMBL4225707 | — | — | 1 | 7.39 |
| CHEMBL4225177 | — | — | 1 | 7.21 |
| CHEMBL4227300 | — | — | 1 | 6.63 |
| CHEMBL4225978 | — | — | 1 | 6.38 |
| CHEMBL210471 | — | — | 1 | 6.37 |
| CHEMBL4227417 | — | — | 1 | 5.81 |
| CHEMBL4228100 | — | — | 1 | 5.55 |
| CHEMBL4227971 | — | — | 1 | 5.46 |
| CHEMBL1289984 | — | — | 1 | 5.31 |
| CHEMBL4225398 | — | — | 1 | 5.21 |
| CHEMBL4225728 | — | — | 1 | 5.18 |
| CHEMBL4226493 | — | — | 1 | 4.17 |
| CHEMBL4228423 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4228478 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4229054 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4224708 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4228792 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4226404 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4225707 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4225177 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4227300 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL4225978 | — | IC50 | = | 422.0 | nM | 6.38 |
| CHEMBL210471 | — | IC50 | = | 431.0 | nM | 6.37 |
| CHEMBL4227417 | — | IC50 | = | 1548.0 | nM | 5.81 |
| CHEMBL4228100 | — | IC50 | = | 2801.0 | nM | 5.55 |
| CHEMBL4227971 | — | IC50 | = | 3465.0 | nM | 5.46 |
| CHEMBL1289984 | — | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL4225398 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4225728 | — | IC50 | = | 6526.0 | nM | 5.18 |
| CHEMBL4226493 | — | IC50 | = | 66879.0 | nM | 4.17 |
| CHEMBL4228423 | — | IC50 | > | 278000.0 | nM | - |