Assay Detail
Functional
CHEMBL4222273
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B expressing wild type reverse transcriptase infected in human MT4 cells assessed as protection against virus-induced cytopathic effect after 5 days by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV-1 K103N/Y181C double mutant strain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.98 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3236715 | — | — | 1 | 8.54 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.41 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.32 |
| CHEMBL4225783 | — | — | 1 | 8.26 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3236715 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4225783 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 440.0 | nM | 6.36 |