Assay Detail
Binding
CHEMBL4222547
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Binding affinity biotinylated human GST-tagged DCN1 by ITC method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 6.31 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4099097 | — | — | 1 | 6.85 |
| CHEMBL4096696 | — | — | 1 | 6.16 |
| CHEMBL4102019 | — | — | 1 | 6.16 |
| CHEMBL4078680 | — | — | 1 | 6.07 |
| CHEMBL4086524 | — | — | 1 | - |
| CHEMBL4226502 | — | — | 1 | - |
| CHEMBL4104419 | — | — | 1 | - |
| CHEMBL4063514 | — | — | 1 | - |
| CHEMBL4072130 | — | — | 1 | - |
| CHEMBL4103922 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4099097 | — | Kd | = | 140.0 | nM | 6.85 |
| CHEMBL4096696 | — | Kd | = | 700.0 | nM | 6.16 |
| CHEMBL4102019 | — | Kd | = | 700.0 | nM | 6.16 |
| CHEMBL4078680 | — | Kd | = | 860.0 | nM | 6.07 |
| CHEMBL4086524 | — | Kd | - | — | - | |
| CHEMBL4226502 | — | Kd | - | — | - | |
| CHEMBL4104419 | — | Kd | - | — | - | |
| CHEMBL4063514 | — | Kd | - | — | - | |
| CHEMBL4072130 | — | Kd | - | — | - | |
| CHEMBL4103922 | — | Kd | - | — | - |