Assay Detail
Functional
CHEMBL4222555
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Growth inhibition of human HCC95 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC95 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 4.45 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4063514 | — | — | 1 | 4.68 |
| CHEMBL4072130 | — | — | 1 | 4.34 |
| CHEMBL4099097 | — | — | 1 | 4.33 |
| CHEMBL4086524 | — | — | 1 | - |
| CHEMBL4096696 | — | — | 1 | - |
| CHEMBL4078680 | — | — | 1 | - |
| CHEMBL4226502 | — | — | 1 | - |
| CHEMBL4104419 | — | — | 1 | - |
| CHEMBL4102019 | — | — | 1 | - |
| CHEMBL4103922 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4063514 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4072130 | — | EC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL4099097 | — | EC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL4086524 | — | EC50 | > | 32000.0 | nM | - |
| CHEMBL4096696 | — | EC50 | > | 23000.0 | nM | - |
| CHEMBL4078680 | — | EC50 | > | 40000.0 | nM | - |
| CHEMBL4226502 | — | EC50 | > | 23000.0 | nM | - |
| CHEMBL4104419 | — | EC50 | > | 40000.0 | nM | - |
| CHEMBL4102019 | — | EC50 | > | 40000.0 | nM | - |
| CHEMBL4103922 | — | EC50 | > | 40000.0 | nM | - |