Assay Detail
Binding
CHEMBL4222653
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Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 40 residues) production measured after 24 hrs
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
New phenylaniline derivatives as modulators of amyloid protein precursor metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.40 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317760 | — | — | 1 | 5.82 |
| CHEMBL97247 | — | — | 1 | 5.77 |
| CHEMBL319756 | — | — | 1 | 5.70 |
| CHEMBL4226945 | — | — | 1 | 5.64 |
| CHEMBL4227472 | — | — | 1 | 5.60 |
| CHEMBL94521 | — | — | 1 | 5.51 |
| CHEMBL682 | AMODIAQUINE | 4.0 | 1 | 5.40 |
| CHEMBL4226951 | — | — | 1 | 5.39 |
| CHEMBL138623 | — | — | 1 | 5.35 |
| CHEMBL4226025 | — | — | 1 | 5.34 |
| CHEMBL167970 | — | — | 1 | 5.29 |
| CHEMBL4228998 | — | — | 1 | 5.21 |
| CHEMBL4225563 | — | — | 1 | 5.18 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 5.16 |
| CHEMBL4225842 | — | — | 1 | 5.09 |
| CHEMBL451753 | — | — | 1 | 5.00 |
| CHEMBL4227963 | — | — | 1 | - |
| CHEMBL4226530 | — | — | 1 | - |
| CHEMBL4227244 | — | — | 1 | - |
| CHEMBL4227708 | — | — | 1 | - |
| CHEMBL4226641 | — | — | 1 | - |
| CHEMBL4226598 | — | — | 1 | - |
| CHEMBL4226906 | — | — | 1 | - |
| CHEMBL4226332 | — | — | 1 | - |
| CHEMBL4226959 | — | — | 1 | - |
| CHEMBL4225384 | — | — | 1 | - |
| CHEMBL4226684 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317760 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL97247 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL319756 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4226945 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4227472 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL94521 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL682 | AMODIAQUINE | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4226951 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL138623 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4226025 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL167970 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4228998 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4225563 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4225842 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL451753 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4227963 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4226530 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4227244 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4227708 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4226641 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4226598 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4226906 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4226332 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4226959 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4225384 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4226684 | — | IC50 | > | 10000.0 | nM | - |