Assay Detail
Binding
CHEMBL4222654
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Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 42 residues) production measured after 24 hrs by ELISA
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
New phenylaniline derivatives as modulators of amyloid protein precursor metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.24 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4226945 | — | — | 1 | 5.72 |
| CHEMBL319756 | — | — | 1 | 5.68 |
| CHEMBL317760 | — | — | 1 | 5.55 |
| CHEMBL97247 | — | — | 1 | 5.54 |
| CHEMBL4226951 | — | — | 1 | 5.33 |
| CHEMBL4227472 | — | — | 1 | 5.31 |
| CHEMBL682 | AMODIAQUINE | 4.0 | 1 | 5.27 |
| CHEMBL4226025 | — | — | 1 | 5.22 |
| CHEMBL94521 | — | — | 1 | 5.15 |
| CHEMBL4225563 | — | — | 1 | 5.10 |
| CHEMBL4228998 | — | — | 1 | 5.03 |
| CHEMBL138623 | — | — | 1 | 4.98 |
| CHEMBL167970 | — | — | 1 | 4.95 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.89 |
| CHEMBL451753 | — | — | 1 | 4.86 |
| CHEMBL4227963 | — | — | 1 | - |
| CHEMBL4226530 | — | — | 1 | - |
| CHEMBL4227244 | — | — | 1 | - |
| CHEMBL4227708 | — | — | 1 | - |
| CHEMBL4226641 | — | — | 1 | - |
| CHEMBL4226598 | — | — | 1 | - |
| CHEMBL4226906 | — | — | 1 | - |
| CHEMBL4226332 | — | — | 1 | - |
| CHEMBL4226959 | — | — | 1 | - |
| CHEMBL4225842 | — | — | 1 | - |
| CHEMBL4225384 | — | — | 1 | - |
| CHEMBL4226684 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4226945 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL319756 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL317760 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL97247 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4226951 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4227472 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL682 | AMODIAQUINE | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4226025 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL94521 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4225563 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4228998 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL138623 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL167970 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL451753 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL4227963 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4226530 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4227244 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4227708 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4226641 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4226598 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4226906 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4226332 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4226959 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4225842 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4225384 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4226684 | — | IC50 | > | 10000.0 | nM | - |