Assay Detail
Functional
CHEMBL4222675
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human DLD1 cells after 72 hrs by alamar blue assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.34 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4228654 | — | — | 1 | 6.14 |
| CHEMBL4225287 | — | — | 1 | 5.68 |
| CHEMBL4227817 | — | — | 1 | 5.57 |
| CHEMBL4224859 | — | — | 1 | 5.55 |
| CHEMBL4227886 | — | — | 1 | 5.19 |
| CHEMBL4228394 | — | — | 1 | 5.14 |
| CHEMBL4225224 | — | — | 1 | 5.06 |
| CHEMBL4228363 | — | — | 1 | 4.92 |
| CHEMBL1231683 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4228654 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4225287 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4227817 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4224859 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4227886 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4228394 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4225224 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL4228363 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL1231683 | — | IC50 | = | 14200.0 | nM | 4.85 |