Assay Detail
Functional
CHEMBL4222676
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Antiproliferative activity against human HCT116 cells after 72 hrs by alamar blue assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.33 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4228654 | — | — | 1 | 5.92 |
| CHEMBL4224859 | — | — | 1 | 5.60 |
| CHEMBL4225287 | — | — | 1 | 5.58 |
| CHEMBL4227817 | — | — | 1 | 5.57 |
| CHEMBL4228363 | — | — | 1 | 5.20 |
| CHEMBL4228394 | — | — | 1 | 4.93 |
| CHEMBL4227886 | — | — | 1 | 4.93 |
| CHEMBL4225224 | — | — | 1 | 4.92 |
| CHEMBL1231683 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4228654 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4224859 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4225287 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4227817 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4228363 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4228394 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL4227886 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL4225224 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL1231683 | — | IC50 | - | — | - |