Assay Detail
Binding
CHEMBL4222695
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PIM2 (unknown origin) expressed in human U2OS cells assessed as reduction in BAD substrate phosphorylation by ELISA
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-2 (CHEMBL4523) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.19 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4229130 | — | — | 1 | 5.72 |
| CHEMBL4227817 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4229130 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4227817 | — | IC50 | = | 22000.0 | nM | 4.66 |