Assay Detail
Binding
CHEMBL4222826
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human N-terminal His6-tagged Pin1 PPIase activity expressed in Escherichia coli BL21 using Suc-Ala-Glu-cis-Pro-Phe-4-nitroanilide as substrate preincubated for 10 mins followed by substrate addition monitored for 90 secs by protease enzyme coupled based spectrophotometric analysis
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (CHEMBL2288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 5.24 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL585917 | — | — | 1 | 7.30 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 6.09 |
| CHEMBL4225962 | — | — | 1 | 5.78 |
| CHEMBL4227633 | — | — | 1 | 5.66 |
| CHEMBL4224912 | — | — | 1 | 5.65 |
| CHEMBL4225484 | — | — | 1 | 5.60 |
| CHEMBL3322225 | — | — | 1 | 5.53 |
| CHEMBL4229104 | — | — | 1 | 5.46 |
| CHEMBL4225167 | — | — | 1 | 5.39 |
| CHEMBL4225677 | — | — | 1 | 5.39 |
| CHEMBL4227675 | — | — | 1 | 5.36 |
| CHEMBL4228988 | — | — | 1 | 5.30 |
| CHEMBL4228852 | — | — | 1 | 5.28 |
| CHEMBL43612 | JUGLONE | — | 1 | 5.23 |
| CHEMBL4228894 | — | — | 1 | 5.18 |
| CHEMBL4226619 | — | — | 1 | 5.14 |
| CHEMBL4227465 | — | — | 1 | 5.14 |
| CHEMBL4226274 | — | — | 1 | 5.08 |
| CHEMBL4225761 | — | — | 1 | 5.04 |
| CHEMBL4225018 | — | — | 1 | 5.01 |
| CHEMBL4228251 | — | — | 1 | 4.86 |
| CHEMBL4226801 | — | — | 1 | 4.78 |
| CHEMBL4228970 | — | — | 1 | 4.72 |
| CHEMBL4224760 | — | — | 1 | 4.70 |
| CHEMBL4225692 | — | — | 1 | 4.65 |
| CHEMBL4229041 | — | — | 1 | 4.57 |
| CHEMBL4226537 | — | — | 1 | 4.47 |
| CHEMBL4226357 | — | — | 1 | 4.47 |
| CHEMBL4227088 | — | — | 1 | - |
| CHEMBL4225874 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL585917 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL38 | TRETINOIN | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4225962 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL4227633 | — | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL4224912 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL4225484 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL3322225 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL4229104 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL4225167 | — | IC50 | = | 4080.0 | nM | 5.39 |
| CHEMBL4225677 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL4227675 | — | IC50 | = | 4360.0 | nM | 5.36 |
| CHEMBL4228988 | — | IC50 | = | 5040.0 | nM | 5.30 |
| CHEMBL4228852 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL43612 | JUGLONE | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4228894 | — | IC50 | = | 6660.0 | nM | 5.18 |
| CHEMBL4226619 | — | IC50 | = | 7270.0 | nM | 5.14 |
| CHEMBL4227465 | — | IC50 | = | 7280.0 | nM | 5.14 |
| CHEMBL4226274 | — | IC50 | = | 8330.0 | nM | 5.08 |
| CHEMBL4225761 | — | IC50 | = | 9050.0 | nM | 5.04 |
| CHEMBL4225018 | — | IC50 | = | 9870.0 | nM | 5.01 |
| CHEMBL4228251 | — | IC50 | = | 13870.0 | nM | 4.86 |
| CHEMBL4226801 | — | IC50 | = | 16550.0 | nM | 4.78 |
| CHEMBL4228970 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL4224760 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL4225692 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL4229041 | — | IC50 | = | 26670.0 | nM | 4.57 |
| CHEMBL4226537 | — | IC50 | = | 34040.0 | nM | 4.47 |
| CHEMBL4226357 | — | IC50 | = | 33500.0 | nM | 4.47 |
| CHEMBL4224906 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4225916 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4226348 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1241353 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4226104 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4227732 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4226887 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4227405 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4226020 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4227941 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4227356 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4228192 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4226558 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4227407 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4228271 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4228140 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4225606 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4225874 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4227088 | — | IC50 | > | 100000.0 | nM | - |