Assay Detail
Functional
CHEMBL4222840
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Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.61 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 7.33 |
| CHEMBL4225565 | — | — | 1 | 5.88 |
| CHEMBL4226151 | — | — | 1 | 5.65 |
| CHEMBL4226937 | — | — | 1 | 5.56 |
| CHEMBL4226676 | — | — | 1 | 5.30 |
| CHEMBL4225951 | — | — | 1 | 5.29 |
| CHEMBL4225306 | — | — | 1 | 5.25 |
| CHEMBL4228518 | — | — | 1 | 5.20 |
| CHEMBL4225777 | — | — | 1 | 5.02 |
| CHEMBL4227084 | — | — | 1 | - |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 47.2 | nM | 7.33 |
| CHEMBL4225565 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL4226151 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL4226937 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL4226676 | — | IC50 | = | 4990.0 | nM | 5.30 |
| CHEMBL4225951 | — | IC50 | = | 5110.0 | nM | 5.29 |
| CHEMBL4225306 | — | IC50 | = | 5580.0 | nM | 5.25 |
| CHEMBL4228518 | — | IC50 | = | 6260.0 | nM | 5.20 |
| CHEMBL4225777 | — | IC50 | = | 9610.0 | nM | 5.02 |
| CHEMBL4227084 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL939 | GEFITINIB | IC50 | > | 10000.0 | nM | - |