Assay Detail
Binding
CHEMBL4222844
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type EGFR (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.75 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 8.85 |
| CHEMBL4226676 | — | — | 1 | 8.80 |
| CHEMBL4228518 | — | — | 1 | 8.60 |
| CHEMBL4227084 | — | — | 1 | - |
| CHEMBL4225951 | — | — | 1 | - |
| CHEMBL4226937 | — | — | 1 | - |
| CHEMBL4225777 | — | — | 1 | - |
| CHEMBL4225565 | — | — | 1 | - |
| CHEMBL4226151 | — | — | 1 | - |
| CHEMBL4225306 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4226676 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4228518 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4227084 | — | IC50 | - | — | - | |
| CHEMBL4225951 | — | IC50 | - | — | - | |
| CHEMBL4226937 | — | IC50 | - | — | - | |
| CHEMBL4225777 | — | IC50 | - | — | - | |
| CHEMBL4225565 | — | IC50 | - | — | - | |
| CHEMBL4226151 | — | IC50 | - | — | - | |
| CHEMBL4225306 | — | IC50 | - | — | - |