Assay Detail
Binding
CHEMBL4223221
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human cathepsin B
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.74 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4228800 | — | — | 1 | 6.15 |
| CHEMBL1215628 | — | — | 1 | 6.01 |
| CHEMBL4227965 | — | — | 1 | 5.96 |
| CHEMBL4228399 | — | — | 1 | 5.90 |
| CHEMBL4227295 | — | — | 1 | 5.76 |
| CHEMBL4226767 | — | — | 1 | 5.66 |
| CHEMBL4225367 | — | — | 1 | 5.65 |
| CHEMBL4228143 | — | — | 1 | 5.63 |
| CHEMBL4224829 | — | — | 1 | 5.62 |
| CHEMBL4228926 | — | — | 1 | 5.60 |
| CHEMBL4228861 | — | — | 1 | 5.56 |
| CHEMBL4228343 | — | — | 1 | 5.39 |
| CHEMBL4225099 | — | — | 1 | - |
| CHEMBL4227619 | — | — | 1 | - |
| CHEMBL4227566 | — | — | 1 | - |
| CHEMBL4228604 | — | — | 1 | - |
| CHEMBL4229174 | — | — | 1 | - |
| CHEMBL4228081 | — | — | 1 | - |
| CHEMBL4228920 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4228800 | — | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL1215628 | — | IC50 | = | 987.0 | nM | 6.01 |
| CHEMBL4227965 | — | IC50 | = | 1104.0 | nM | 5.96 |
| CHEMBL4228399 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4227295 | — | IC50 | = | 1721.0 | nM | 5.76 |
| CHEMBL4226767 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL4225367 | — | IC50 | = | 2241.0 | nM | 5.65 |
| CHEMBL4228143 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL4224829 | — | IC50 | = | 2371.0 | nM | 5.62 |
| CHEMBL4228926 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4228861 | — | IC50 | = | 2751.0 | nM | 5.56 |
| CHEMBL4228343 | — | IC50 | = | 4080.0 | nM | 5.39 |
| CHEMBL4225099 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4227619 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4227566 | — | IC50 | - | — | - | |
| CHEMBL4228604 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4229174 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4228081 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4228920 | — | IC50 | > | 5000.0 | nM | - |