Assay Detail
Functional
CHEMBL4223746
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Cytotoxicity against human OVCAR3 cells measured after 24 to 72 hrs by SRB assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OVCAR-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.20 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.96 |
| CHEMBL3298730 | — | — | 1 | 6.54 |
| CHEMBL4228339 | — | — | 1 | 6.44 |
| CHEMBL4225076 | — | — | 1 | 6.43 |
| CHEMBL4228856 | — | — | 1 | 6.35 |
| CHEMBL4224710 | — | — | 1 | 6.24 |
| CHEMBL1929098 | — | — | 1 | 6.16 |
| CHEMBL4225831 | — | — | 1 | 6.09 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.54 |
| CHEMBL460047 | ACUTISSIMALIGNAN A | — | 1 | 5.32 |
| CHEMBL4225504 | — | — | 1 | 5.12 |
| CHEMBL4224824 | — | — | 1 | - |
| CHEMBL4225094 | — | — | 1 | - |
| CHEMBL4229170 | — | — | 1 | - |
| CHEMBL4226072 | — | — | 1 | - |
| CHEMBL4229112 | — | — | 1 | - |
| CHEMBL4225615 | — | — | 1 | - |
| CHEMBL4226342 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3298730 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4228339 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4225076 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4228856 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4224710 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL1929098 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4225831 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL460047 | ACUTISSIMALIGNAN A | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4225504 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4224824 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4225094 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4229170 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4226072 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4229112 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4225615 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4226342 | — | IC50 | > | 10000.0 | nM | - |