Assay Detail
Functional
CHEMBL4224229
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Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.41 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4227747 | — | — | 1 | 6.40 |
| CHEMBL38434 | BREQUINAR | 2.0 | 1 | 6.26 |
| CHEMBL4227217 | — | — | 1 | 5.57 |
| CHEMBL3600460 | — | — | 1 | 5.46 |
| CHEMBL4228971 | — | — | 1 | 5.32 |
| CHEMBL4224965 | — | — | 1 | 5.15 |
| CHEMBL4227722 | — | — | 1 | 5.15 |
| CHEMBL4228712 | — | — | 1 | 5.03 |
| CHEMBL4226472 | — | — | 1 | 4.94 |
| CHEMBL4225759 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4227747 | — | IC50 | = | 401.0 | nM | 6.40 |
| CHEMBL38434 | BREQUINAR | IC50 | = | 544.0 | nM | 6.26 |
| CHEMBL4227217 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL3600460 | — | IC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL4228971 | — | IC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL4224965 | — | IC50 | = | 7120.0 | nM | 5.15 |
| CHEMBL4227722 | — | IC50 | = | 7080.0 | nM | 5.15 |
| CHEMBL4228712 | — | IC50 | = | 9280.0 | nM | 5.03 |
| CHEMBL4226472 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL4225759 | — | IC50 | = | 15300.0 | nM | 4.82 |