Assay Detail
Functional
CHEMBL4231436
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 after 72 hrs by lactate dehydrogenase assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.00 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.58 |
| CHEMBL4242227 | — | — | 1 | 6.39 |
| CHEMBL4238335 | — | — | 1 | 6.34 |
| CHEMBL4238529 | — | — | 1 | 6.29 |
| CHEMBL4245012 | — | — | 1 | 6.28 |
| CHEMBL4242704 | — | — | 1 | 6.26 |
| CHEMBL4245471 | — | — | 1 | 6.14 |
| CHEMBL537152 | — | — | 1 | 6.11 |
| CHEMBL4246869 | — | — | 1 | 6.06 |
| CHEMBL4249272 | — | — | 1 | 6.00 |
| CHEMBL4242609 | — | — | 1 | 6.00 |
| CHEMBL4246056 | — | — | 1 | 5.96 |
| CHEMBL4238087 | — | — | 1 | 5.96 |
| CHEMBL4240668 | — | — | 1 | 5.92 |
| CHEMBL4241797 | — | — | 1 | 5.68 |
| CHEMBL4248315 | — | — | 1 | 5.68 |
| CHEMBL4246962 | — | — | 1 | 5.60 |
| CHEMBL4244830 | — | — | 1 | 5.46 |
| CHEMBL4245585 | — | — | 1 | 5.36 |
| CHEMBL4241601 | — | — | 1 | 5.00 |
| CHEMBL4248815 | — | — | 1 | - |
| CHEMBL4238777 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4242227 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4238335 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4238529 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4245012 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4242704 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4245471 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL537152 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4246869 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4249272 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4242609 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4246056 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4238087 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4240668 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4241797 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4248315 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4246962 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4244830 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4245585 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4241601 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4248815 | — | IC50 | > | 13000.0 | nM | - |
| CHEMBL4238777 | — | IC50 | > | 13000.0 | nM | - |