Assay Detail
Functional
CHEMBL4231437
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs by lactate dehydrogenase assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.54 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.51 |
| CHEMBL4242704 | — | — | 1 | 6.18 |
| CHEMBL4240668 | — | — | 1 | 5.85 |
| CHEMBL4245012 | — | — | 1 | 5.85 |
| CHEMBL4242227 | — | — | 1 | 5.82 |
| CHEMBL4249272 | — | — | 1 | 5.82 |
| CHEMBL4238529 | — | — | 1 | 5.73 |
| CHEMBL4245471 | — | — | 1 | 5.66 |
| CHEMBL537152 | — | — | 1 | 5.64 |
| CHEMBL4246869 | — | — | 1 | 5.62 |
| CHEMBL4242609 | — | — | 1 | 5.52 |
| CHEMBL4238335 | — | — | 1 | 5.47 |
| CHEMBL4248315 | — | — | 1 | 5.37 |
| CHEMBL4246962 | — | — | 1 | 5.26 |
| CHEMBL4238087 | — | — | 1 | 5.20 |
| CHEMBL4246056 | — | — | 1 | 5.10 |
| CHEMBL4238777 | — | — | 1 | 5.10 |
| CHEMBL4241797 | — | — | 1 | 5.10 |
| CHEMBL4244830 | — | — | 1 | 5.04 |
| CHEMBL4245585 | — | — | 1 | 5.02 |
| CHEMBL4248815 | — | — | 1 | - |
| CHEMBL4241601 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4242704 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4240668 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4245012 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4242227 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4249272 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4238529 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL4245471 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL537152 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4246869 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4242609 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4238335 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4248315 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4246962 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4238087 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4246056 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4238777 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4241797 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4244830 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4245585 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4248815 | — | IC50 | > | 13000.0 | nM | - |
| CHEMBL4241601 | — | IC50 | > | 15000.0 | nM | - |