Assay Detail
Functional
CHEMBL4231438
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Gametocytocidal activity against Plasmodium falciparum 3D7 elo1-pfs16-CBG99 late-stage (4 to 5) gametocytes assessed as inhibition of parasite viability after 72 hrs by luciferase reporter assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.76 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207990 | EPOXOMYCIN | — | 1 | 8.15 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | 4.0 | 1 | 7.52 |
| CHEMBL4245012 | — | — | 1 | 6.08 |
| CHEMBL4245471 | — | — | 1 | 6.07 |
| CHEMBL4240668 | — | — | 1 | 5.96 |
| CHEMBL4238529 | — | — | 1 | 5.96 |
| CHEMBL537152 | — | — | 1 | 5.92 |
| CHEMBL4242609 | — | — | 1 | 5.85 |
| CHEMBL4246869 | — | — | 1 | 5.85 |
| CHEMBL4249272 | — | — | 1 | 5.85 |
| CHEMBL4242227 | — | — | 1 | 5.72 |
| CHEMBL4238335 | — | — | 1 | 5.40 |
| CHEMBL4246056 | — | — | 1 | 5.36 |
| CHEMBL4242704 | — | — | 1 | 5.32 |
| CHEMBL4248315 | — | — | 1 | 5.23 |
| CHEMBL4241797 | — | — | 1 | 5.22 |
| CHEMBL4245585 | — | — | 1 | 5.08 |
| CHEMBL4244830 | — | — | 1 | 5.07 |
| CHEMBL4241601 | — | — | 1 | 4.93 |
| CHEMBL4238087 | — | — | 1 | 4.74 |
| CHEMBL4248815 | — | — | 1 | - |
| CHEMBL4238777 | — | — | 1 | - |
| CHEMBL4246962 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207990 | EPOXOMYCIN | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4245012 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4245471 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4240668 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4238529 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL537152 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4242609 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4246869 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4249272 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4242227 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4238335 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4246056 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4242704 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4248315 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4241797 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4245585 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4244830 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4241601 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL4238087 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL4248815 | — | IC50 | > | 13000.0 | nM | - |
| CHEMBL4238777 | — | IC50 | > | 26000.0 | nM | - |
| CHEMBL4246962 | — | IC50 | > | 24000.0 | nM | - |