Assay Detail
Binding
CHEMBL4231476
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CaV1.2 channel in rat tail artery myocytes assessed as reduction in Ba2+ current at -50 mV holding potential by whole-cell patch-clamp assay
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-dependent L-type calcium channel subunit alpha-1C (CHEMBL3762) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 2 | - | - |
| IC50 | 1 | 5.48 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4246869 | — | — | 2 | 5.48 |
| CHEMBL537152 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4246869 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4246869 | — | Inhibition | - | % | - | |
| CHEMBL537152 | — | Inhibition | - | % | - |