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Assay Detail

CHEMBL4232680

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human IDE using insulin as substrate preincubated for 10 mis followed by substrate addition and measured after 30 mins
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Insulin-degrading enzyme (CHEMBL1293287)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Druggability Assessment of Targets Used in Kinetic Target-Guided Synthesis.
Unver MY, Gierse RM, Ritchie H, Hirsch AKH.
J Med Chem (2018) 61 : 9395 -9409
PubMed 29873484 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.25 7.25

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4241044 1 7.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4241044 IC50 = 56.0 nM 7.25