Assay Detail
Binding
CHEMBL4233279
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PKAalpha (1 to 351 residues) (unknown origin) using Leu-Arg-Arg-Ala-Ser-Leu-Gly as substrate by pyruvate kinase-lactate dehydrogenase coupled assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cAMP-dependent protein kinase catalytic subunit alpha (CHEMBL4101) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
ROCK inhibitors 2. Improving potency, selectivity and solubility through the application of rationally designed solubilizing groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.05 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4242549 | — | — | 1 | 6.24 |
| CHEMBL3581121 | — | — | 1 | 5.85 |
| CHEMBL4237479 | — | — | 1 | - |
| CHEMBL4251324 | — | — | 1 | - |
| CHEMBL4241204 | — | — | 1 | - |
| CHEMBL4245507 | — | — | 1 | - |
| CHEMBL4241299 | — | — | 1 | - |
| CHEMBL4249314 | — | — | 1 | - |
| CHEMBL4241689 | — | — | 1 | - |
| CHEMBL4240949 | — | — | 1 | - |
| CHEMBL4248852 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4242549 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL3581121 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL4237479 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL4251324 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL4241204 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL4245507 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL4241299 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL4249314 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL4241689 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL4240949 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL4248852 | — | Ki | > | 4000.0 | nM | - |