Assay Detail
Binding
CHEMBL4233439
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SGLT2 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of nitric oxide releasing derivatives of dapagliflozin as potential anti-diabetic and anti-thrombotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.54 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429910 | DAPAGLIFLOZIN | 4.0 | 1 | 8.96 |
| CHEMBL2048484 | CANAGLIFLOZIN ANHYDROUS | 4.0 | 1 | 8.66 |
| CHEMBL1093423 | LUSEOGLIFLOZIN | 2.0 | 1 | 8.64 |
| CHEMBL2107830 | EMPAGLIFLOZIN | 4.0 | 1 | 8.51 |
| CHEMBL2110731 | TOFOGLIFLOZIN ANHYDROUS | 4.0 | 1 | 8.40 |
| CHEMBL2018096 | IPRAGLIFLOZIN | 4.0 | 1 | 8.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429910 | DAPAGLIFLOZIN | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL2048484 | CANAGLIFLOZIN ANHYDROUS | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1093423 | LUSEOGLIFLOZIN | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL2107830 | EMPAGLIFLOZIN | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL2110731 | TOFOGLIFLOZIN ANHYDROUS | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2018096 | IPRAGLIFLOZIN | IC50 | = | 8.4 | nM | 8.08 |