Compound Detail
CHEMBL2048484
CANAGLIFLOZIN ANHYDROUS 💊 Approved Drug
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💊 Approved Drug
Cc1ccc([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1Cc1ccc(-c2ccc(F)cc2)s1
Basic Information
| ChEMBL ID | CHEMBL2048484 |
| Name | CANAGLIFLOZIN ANHYDROUS |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | XTNGUQKDFGDXSJ-ZXGKGEBGSA-N |
| Therapeutic | ✓ Yes |
2
Targets
14
Activities
2
Assay Types
0
PK Parameters
20
Publications
3
Known Names
Molecular Properties
444.5
MW (Da)
2.97
ALogP
6
HBA
4
HBD
90.2
PSA (Ų)
0.49
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2011 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Activity Summary
IC50 12 meas. best 8.66
EC50 2 meas. best 8.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium/glucose cotransporter 2 CHEMBL3884 | EC50 | 8.66 | 8.66 | 2.2 | 1 |
| Sodium/glucose cotransporter 2 CHEMBL3884 | IC50 | 8.66 | 8.4914 | 2.2 | 7 |
| Sodium/glucose cotransporter 1 CHEMBL4979 | IC50 | 6.58 | 6.176 | 265.0 | 5 |
| Sodium/glucose cotransporter 1 CHEMBL4979 | EC50 | 6.04 | 6.04 | 910.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine