Assay Detail
Binding
CHEMBL4343612
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human SGLT1
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthetic strategy and SAR studies of C-glucoside heteroaryls as SGLT2 inhibitor: A review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.91 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3039507 | SOTAGLIFLOZIN | 4.0 | 1 | 7.46 |
| CHEMBL245067 | PHLORIZIN | — | 1 | 6.68 |
| CHEMBL2048484 | CANAGLIFLOZIN ANHYDROUS | 4.0 | 1 | 6.17 |
| CHEMBL429910 | DAPAGLIFLOZIN | 4.0 | 1 | 5.86 |
| CHEMBL2018096 | IPRAGLIFLOZIN | 4.0 | 1 | 5.73 |
| CHEMBL1770248 | ERTUGLIFLOZIN | 4.0 | 1 | 5.71 |
| CHEMBL1093423 | LUSEOGLIFLOZIN | 2.0 | 1 | 5.40 |
| CHEMBL4521016 | — | — | 1 | 5.08 |
| CHEMBL2110731 | TOFOGLIFLOZIN ANHYDROUS | 4.0 | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3039507 | SOTAGLIFLOZIN | IC50 | = | 34.6 | nM | 7.46 |
| CHEMBL245067 | PHLORIZIN | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2048484 | CANAGLIFLOZIN ANHYDROUS | IC50 | = | 684.0 | nM | 6.17 |
| CHEMBL429910 | DAPAGLIFLOZIN | IC50 | = | 1391.0 | nM | 5.86 |
| CHEMBL2018096 | IPRAGLIFLOZIN | IC50 | = | 1876.0 | nM | 5.73 |
| CHEMBL1770248 | ERTUGLIFLOZIN | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL1093423 | LUSEOGLIFLOZIN | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL4521016 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL2110731 | TOFOGLIFLOZIN ANHYDROUS | IC50 | = | 8444.0 | nM | 5.07 |