Compound Detail
CHEMBL3039507
SOTAGLIFLOZIN 💊 Approved Drug
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💊 Approved Drug
CCOc1ccc(Cc2cc([C@@H]3O[C@H](SC)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)cc1
Basic Information
| ChEMBL ID | CHEMBL3039507 |
| Name | SOTAGLIFLOZIN |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | QKDRXGFQVGOQKS-CRSSMBPESA-N |
| Therapeutic | ✓ Yes |
2
Targets
12
Activities
1
Assay Types
7
PK Parameters
20
Publications
10
Known Names
10
Indications
2
Mechanisms
Molecular Properties
424.9
MW (Da)
3.17
ALogP
6
HBA
3
HBD
79.2
PSA (Ų)
0.66
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2019 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Sodium/glucose cotransporter 1 inhibitor | INHIBITOR | Sodium/glucose cotransporter 1 | ✓ | ✓ |
| Sodium/glucose cotransporter 2 inhibitor | INHIBITOR | Sodium/glucose cotransporter 2 | ✓ | ✓ |
Indications
Diabetes Mellitus Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Heart Disease Risk Factors Heart Failure Renal Insufficiency, Chronic Cardiomyopathy, Hypertrophic Kidney Diseases Liver Diseases Cardiomyopathies
ATC Classification
A10BK06
sotagliflozin
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: DRUGS USED IN DIABETES
Activity Summary
IC50 12 meas. best 8.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium/glucose cotransporter 2 CHEMBL3884 | IC50 | 8.82 | 8.78 | 1.5 | 6 |
| Sodium/glucose cotransporter 1 CHEMBL4979 | IC50 | 7.46 | 7.45 | 34.6 | 6 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 824.4 | ng.hr.mL-1 | Mus musculus |
| AUC | 8375.76 | ng.hr.mL-1 | Mus musculus |
| CL | 20.6 | mL.min-1.kg-1 | Mus musculus |
| Cmax | 4973.0 | nM | Mus musculus |
| F | 98.0 | % | Mus musculus |
| T1/2 | 1.39 | hr | Mus musculus |
| T1/2 | 6.52 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine