Assay Detail

CHEMBL4259680

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Binding

Inhibition of SGLT1 (unknown origin)

ChEMBL ↗

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Target

Sodium/glucose cotransporter 1 (CHEMBL4979) ↗

Open DB target context

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Sodium/glucose cotransporter 1 (CHEMBL4979) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Sodium/glucose cotransporter 1

CHEMBL4979

Anchored from Assay target.

Protein identity Sodium/glucose cotransporter 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Sodium/glucose cotransporter 1 (CHEMBL4979) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Sodium-glucose cotransporter 2 (SGLT-2) inhibitors: a new antidiabetic drug class.

da Silva PN, da Conceição RA, do Couto Maia R, de Castro Barbosa ML.
Medchemcomm (2018) 9 : 1273 -1281
PubMed 30151080 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.44	7.44

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3039507	SOTAGLIFLOZIN	4.0	1	7.44

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3039507	SOTAGLIFLOZIN	IC50	=	36.0	nM	7.44