Assay Detail
Binding
CHEMBL4343613
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human SGLT2
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthetic strategy and SAR studies of C-glucoside heteroaryls as SGLT2 inhibitor: A review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.57 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3125150 | — | — | 1 | 9.17 |
| CHEMBL1770248 | ERTUGLIFLOZIN | 4.0 | 1 | 9.06 |
| CHEMBL429910 | DAPAGLIFLOZIN | 4.0 | 1 | 8.95 |
| CHEMBL3039507 | SOTAGLIFLOZIN | 4.0 | 1 | 8.82 |
| CHEMBL1093423 | LUSEOGLIFLOZIN | 2.0 | 1 | 8.65 |
| CHEMBL2110731 | TOFOGLIFLOZIN ANHYDROUS | 4.0 | 1 | 8.54 |
| CHEMBL4521016 | — | — | 1 | 8.51 |
| CHEMBL2048484 | CANAGLIFLOZIN ANHYDROUS | 4.0 | 1 | 8.36 |
| CHEMBL2018096 | IPRAGLIFLOZIN | 4.0 | 1 | 8.13 |
| CHEMBL245067 | PHLORIZIN | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3125150 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL1770248 | ERTUGLIFLOZIN | IC50 | = | 0.877 | nM | 9.06 |
| CHEMBL429910 | DAPAGLIFLOZIN | IC50 | = | 1.12 | nM | 8.95 |
| CHEMBL3039507 | SOTAGLIFLOZIN | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL1093423 | LUSEOGLIFLOZIN | IC50 | = | 2.26 | nM | 8.65 |
| CHEMBL2110731 | TOFOGLIFLOZIN ANHYDROUS | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4521016 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL2048484 | CANAGLIFLOZIN ANHYDROUS | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL2018096 | IPRAGLIFLOZIN | IC50 | = | 7.38 | nM | 8.13 |
| CHEMBL245067 | PHLORIZIN | IC50 | = | 34.6 | nM | 7.46 |