Assay Detail
Binding
CHEMBL4344293
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Inhibition of SGLT2 (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.34 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429910 | DAPAGLIFLOZIN | 4.0 | 1 | 8.96 |
| CHEMBL2048484 | CANAGLIFLOZIN ANHYDROUS | 4.0 | 1 | 8.66 |
| CHEMBL1093423 | LUSEOGLIFLOZIN | 2.0 | 1 | 8.64 |
| CHEMBL2107830 | EMPAGLIFLOZIN | 4.0 | 1 | 8.52 |
| CHEMBL2017954 | — | — | 1 | 8.30 |
| CHEMBL2018096 | IPRAGLIFLOZIN | 4.0 | 1 | 8.13 |
| CHEMBL270766 | SERGLIFLOZIN A | — | 1 | 8.04 |
| CHEMBL4552590 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429910 | DAPAGLIFLOZIN | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL2048484 | CANAGLIFLOZIN ANHYDROUS | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1093423 | LUSEOGLIFLOZIN | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL2107830 | EMPAGLIFLOZIN | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2017954 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2018096 | IPRAGLIFLOZIN | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL270766 | SERGLIFLOZIN A | EC50 | = | 9.2 | nM | 8.04 |
| CHEMBL4552590 | — | EC50 | = | 36.0 | nM | 7.44 |