Assay Detail
Binding
CHEMBL4233573
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Inhibition of Helicobacter pylori ATCC 43504 urease assessed as reduction in ammonia production using urea as substrate preincubated for 1.5 hrs under cell free condition by indophenol method
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Helicobacter pylori NCTC 11637 = CCUG 17874 = ATCC 43504 |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Target
Urease subunit alpha/Urease subunit beta (CHEMBL3885651) ↗| Type | PROTEIN COMPLEX |
| Organism | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) |
Publication
The synthesis and evaluation of phenoxyacylhydroxamic acids as potential agents for Helicobacter pylori infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.21 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4243350 | — | — | 1 | 7.21 |
| CHEMBL4251246 | — | — | 1 | 6.36 |
| CHEMBL4245850 | — | — | 1 | 6.28 |
| CHEMBL2094349 | — | — | 1 | 6.08 |
| CHEMBL4241971 | — | — | 1 | 6.07 |
| CHEMBL4250256 | — | — | 1 | 5.95 |
| CHEMBL4248626 | — | — | 1 | 5.91 |
| CHEMBL4248008 | — | — | 1 | 5.90 |
| CHEMBL4240308 | — | — | 1 | 5.86 |
| CHEMBL4247924 | — | — | 1 | 5.69 |
| CHEMBL4246507 | — | — | 1 | 5.49 |
| CHEMBL2360000 | — | — | 1 | 5.47 |
| CHEMBL569423 | — | — | 1 | 5.38 |
| CHEMBL4250425 | — | — | 1 | 5.29 |
| CHEMBL4245720 | — | — | 1 | 5.27 |
| CHEMBL4247132 | — | — | 1 | 5.17 |
| CHEMBL4246522 | — | — | 1 | 5.08 |
| CHEMBL4240691 | — | — | 1 | 5.04 |
| CHEMBL4239299 | — | — | 1 | 4.98 |
| CHEMBL4245086 | — | — | 1 | 4.98 |
| CHEMBL4239073 | — | — | 1 | 4.88 |
| CHEMBL4245439 | — | — | 1 | 4.72 |
| CHEMBL4250489 | — | — | 1 | 4.57 |
| CHEMBL734 | ACETOHYDROXAMIC ACID | 4.0 | 1 | 4.55 |
| CHEMBL4239970 | — | — | 1 | 4.38 |
| CHEMBL4238717 | — | — | 1 | 4.30 |
| CHEMBL4247495 | — | — | 1 | 4.24 |
| CHEMBL4239124 | — | — | 1 | 4.21 |
| CHEMBL4242735 | — | — | 1 | 4.11 |
| CHEMBL4245159 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4243350 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4251246 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4245850 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2094349 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4241971 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4250256 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL4248626 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL4248008 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL4240308 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL4247924 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL4246507 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL2360000 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL569423 | — | IC50 | = | 4180.0 | nM | 5.38 |
| CHEMBL4250425 | — | IC50 | = | 5090.0 | nM | 5.29 |
| CHEMBL4245720 | — | IC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL4247132 | — | IC50 | = | 6740.0 | nM | 5.17 |
| CHEMBL4246522 | — | IC50 | = | 8350.0 | nM | 5.08 |
| CHEMBL4240691 | — | IC50 | = | 9020.0 | nM | 5.04 |
| CHEMBL4245086 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL4239299 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL4239073 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL4245439 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL4250489 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL734 | ACETOHYDROXAMIC ACID | IC50 | = | 27900.0 | nM | 4.55 |
| CHEMBL4239970 | — | IC50 | = | 41900.0 | nM | 4.38 |
| CHEMBL4238717 | — | IC50 | = | 49500.0 | nM | 4.30 |
| CHEMBL4247495 | — | IC50 | = | 57100.0 | nM | 4.24 |
| CHEMBL4239124 | — | IC50 | = | 62100.0 | nM | 4.21 |
| CHEMBL4242735 | — | IC50 | = | 78500.0 | nM | 4.11 |
| CHEMBL4245159 | — | IC50 | = | 85100.0 | nM | 4.07 |
| CHEMBL4239571 | — | IC50 | = | 94700.0 | nM | 4.02 |
| CHEMBL569422 | — | IC50 | = | 131200.0 | nM | - |
| CHEMBL4242065 | — | IC50 | = | 353200.0 | nM | - |
| CHEMBL4246997 | — | IC50 | = | 153600.0 | nM | - |
| CHEMBL4245261 | — | IC50 | = | 121500.0 | nM | - |
| CHEMBL4238560 | — | IC50 | = | 178700.0 | nM | - |
| CHEMBL4249219 | — | IC50 | = | 144300.0 | nM | - |
| CHEMBL4250127 | — | IC50 | = | 205400.0 | nM | - |