Assay Detail
Functional
CHEMBL4233728
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Cytotoxicity against human WI38 cells after 48 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WI-38 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Anti-acute myeloid leukemia activity of 2-chloro-3-alkyl-1,4-naphthoquinone derivatives through inducing mtDNA damage and GSH depletion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.59 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4241331 | — | — | 1 | 4.82 |
| CHEMBL349147 | — | — | 1 | 4.67 |
| CHEMBL4208719 | — | — | 1 | 4.63 |
| CHEMBL4251451 | — | — | 1 | 4.62 |
| CHEMBL295316 | PLUMBAGIN | 1.0 | 1 | 4.57 |
| CHEMBL4245094 | — | — | 1 | 4.51 |
| CHEMBL4240421 | — | — | 1 | 4.48 |
| CHEMBL4240888 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4241331 | — | IC50 | = | 15020.0 | nM | 4.82 |
| CHEMBL349147 | — | IC50 | = | 21580.0 | nM | 4.67 |
| CHEMBL4208719 | — | IC50 | = | 23210.0 | nM | 4.63 |
| CHEMBL4251451 | — | IC50 | = | 23810.0 | nM | 4.62 |
| CHEMBL295316 | PLUMBAGIN | IC50 | = | 26710.0 | nM | 4.57 |
| CHEMBL4245094 | — | IC50 | = | 31120.0 | nM | 4.51 |
| CHEMBL4240421 | — | IC50 | = | 33010.0 | nM | 4.48 |
| CHEMBL4240888 | — | IC50 | = | 40240.0 | nM | 4.39 |