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Assay Detail

CHEMBL4234437

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of mouse recombinant glycolate oxidase expressed in Escherichia coli using glycolate as substrate by Dixon plot and Cornish-Bowden plot analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

2-Hydroxyacid oxidase 1 (CHEMBL4295985)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1.
Moya-Garzón MD, Martín Higueras C, Peñalver P, Romera M, Fernandes MX, Franco-Montalbán F, Gómez-Vidal JA, Salido E, Díaz-Gavilán M.
J Med Chem (2018) 61 : 7144 -7167
PubMed 30028141 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 4.33 4.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4247590 1 4.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4247590 Ki = 47200.0 nM 4.33