Assay Detail
Binding
CHEMBL4234579
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CaV3.2 expressed in HEK293 cells assessed as suppression of T-current amplitude after 10 mins by whole cell patch clamp method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-dependent T-type calcium channel subunit alpha-1H (CHEMBL1859) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.18 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4248823 | — | — | 1 | 6.58 |
| CHEMBL4249364 | — | — | 1 | 6.41 |
| CHEMBL4238346 | — | — | 1 | 6.34 |
| CHEMBL4251381 | — | — | 1 | 6.32 |
| CHEMBL4240812 | — | — | 1 | 6.30 |
| CHEMBL4245811 | — | — | 1 | 6.19 |
| CHEMBL243148 | SOPHORAFLAVANONE G | — | 1 | 6.00 |
| CHEMBL376915 | — | — | 1 | 6.00 |
| CHEMBL1537093 | — | — | 1 | 6.00 |
| CHEMBL4242828 | — | — | 1 | 5.99 |
| CHEMBL4237637 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4248823 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4249364 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4238346 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4251381 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4240812 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4245811 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL243148 | SOPHORAFLAVANONE G | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL376915 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1537093 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4242828 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL4237637 | — | IC50 | = | 1250.0 | nM | 5.90 |