Compound Detail
CHEMBL4238346
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4238346 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IALKZQGOEOFEMS-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
366.4
MW (Da)
4.55
ALogP
5
HBA
3
HBD
87.0
PSA (Ų)
0.69
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Voltage-dependent T-type calcium channel subunit alpha-1H CHEMBL1859 | IC50 | 6.34 | 6.34 | 460.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Voltage-dependent T-type calcium channel subunit alpha-1H | IC50 | = | 460.0 | nM | 6.34 | Inhibition of human CaV3.2 expressed in HEK293 cells assessed as suppression of ... | 30031654 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30031654 | 10.1016/j.bmc.2018.07.023 | Voltage-dependent T-type calcium channel subunit alpha-1H | 2 |
Data from ChEMBL 36 via Core Engine