Assay Detail
Binding
CHEMBL4234914
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of voltage-dependent L-type calcium channel in Wistar rat 3rd-order mesenteric artery assessed as reduction in norepinephrine-induced vessel contraction by myographic method
18
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Target
Voltage-gated L-type calcium channel (CHEMBL2095177) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Terpenoids with vasorelaxant effects from the Chinese liverwort Scapania carinthiaca.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 12 | - | - |
| EC50 | 6 | 4.97 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4243120 | — | — | 3 | 5.39 |
| CHEMBL4251191 | — | — | 3 | 5.14 |
| CHEMBL4246908 | — | — | 3 | 4.92 |
| CHEMBL4246780 | — | — | 3 | 4.85 |
| CHEMBL4241124 | — | — | 3 | 4.85 |
| CHEMBL4240985 | — | — | 3 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4243120 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4251191 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4246908 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4241124 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4246780 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4240985 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4246780 | — | Inhibition | > | 70.0 | % | - |
| CHEMBL4246908 | — | Inhibition | > | 70.0 | % | - |
| CHEMBL4251191 | — | Inhibition | > | 70.0 | % | - |
| CHEMBL4243120 | — | Inhibition | > | 70.0 | % | - |
| CHEMBL4241124 | — | Inhibition | > | 70.0 | % | - |
| CHEMBL4240985 | — | Inhibition | > | 70.0 | % | - |
| CHEMBL4246780 | — | Inhibition | - | % | - | |
| CHEMBL4246908 | — | Inhibition | - | % | - | |
| CHEMBL4251191 | — | Inhibition | - | % | - | |
| CHEMBL4243120 | — | Inhibition | - | % | - | |
| CHEMBL4241124 | — | Inhibition | - | % | - | |
| CHEMBL4240985 | — | Inhibition | - | % | - |