Assay Detail
Binding
CHEMBL4235172
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human biotinylated HLA-A2 by surface plasmon resonance assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
HLA class I histocompatibility antigen, A alpha chain (CHEMBL2632) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of small molecule inhibitors of adenovirus by disrupting E3-19K/HLA-A2 interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 5.16 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1200798 | TRAZODONE HYDROCHLORIDE | 4.0 | 1 | 5.60 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 1 | 5.60 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 5.60 |
| CHEMBL1200561 | DOXAZOSIN MESYLATE | 4.0 | 1 | 4.80 |
| CHEMBL101253 | VATALANIB | 3.0 | 1 | 4.67 |
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | 4.0 | 1 | 4.66 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1200798 | TRAZODONE HYDROCHLORIDE | Kd | = | 2500.0 | nM | 5.60 |
| CHEMBL296419 | ASTEMIZOLE | Kd | = | 2500.0 | nM | 5.60 |
| CHEMBL267930 | SPIPERONE | Kd | = | 2500.0 | nM | 5.60 |
| CHEMBL1200561 | DOXAZOSIN MESYLATE | Kd | = | 15700.0 | nM | 4.80 |
| CHEMBL101253 | VATALANIB | Kd | = | 21200.0 | nM | 4.67 |
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | Kd | = | 22000.0 | nM | 4.66 |
| CHEMBL54 | HALOPERIDOL | Kd | < | 10000.0 | nM | - |